AP Biologymediummcq1 pt

Why is the lagging strand synthesized in Okazaki fragments?

A.DNA polymerase can only add nucleotides in the 5′→3′ direction
B.The lagging strand contains RNA
C.Helicase works only on one strand
D.Ligase cannot join long strands

Explanation

Core Concept

DNA polymerases synthesize new DNA only in the 5′→3′ direction. Because the parental strands are antiparallel, one new strand can be synthesized continuously toward the replication fork, whereas the other is synthesized discontinuously in fragments away from the fork and later joined. The lagging strand is not synthesized 'backward'; both new strands are made 5′→3′.

Correct Answer

ADNA polymerase can only add nucleotides in the 5′→3′ direction

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