Apentix/AP Biology/Unit 2: Cell Structure and Function/Question
AP Biologymediummcq1 pt

In familial hypercholesterolemia, liver cells carry LDL receptors that fail to bind and cluster properly at the cell surface. Which direct consequence follows for these cells?

A.They cannot internalize LDL by receptor mediated endocytosis, so blood cholesterol stays high
B.Their membranes stop forming vesicles entirely because clathrin requires LDL to assemble
C.LDL particles instead diffuse directly through the phospholipid bilayer
D.The cells compensate by exporting cholesterol faster through exocytosis

Explanation

Core Concept

LDL receptors bind circulating LDL and concentrate the receptor-cargo complexes in coated pits for receptor-mediated endocytosis. Defective binding or clustering greatly reduces normal hepatic LDL uptake and clearance, allowing plasma LDL to rise. This receptor pathway is the major physiological clearance route, but it is too strong to call it literally the only possible route by which any LDL can enter a cell.

Correct Answer

AThey cannot internalize LDL by receptor mediated endocytosis, so blood cholesterol stays high

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