Apentix/AP Biology/Unit 2: Cell Structure and Function/Question
AP Biologymediummcq1 pt

A drug prevents dynamin from hydrolyzing GTP in cultured cells. Which step of clathrin mediated endocytosis fails first?

A.Cargo binding to receptors at the cell surface
B.Clathrin assembly into coated pits on the cytoplasmic face
C.Fusion of completed vesicles with early endosomes
D.Scission of the deeply invaginated pit from the plasma membrane

Explanation

Core Concept

Dynamin assembles as a collar around the stalk connecting a mature coated pit to the surface. Hydrolysis of its bound GTP powers the constriction that pinches the neck free into the cytosol. When that step fails, pits deepen normally but cannot detach, while upstream cargo capture and coat assembly continue unaffected.

Correct Answer

DScission of the deeply invaginated pit from the plasma membrane

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