Based on the data, which of the following mutations would most likely result in a nonfunctional protein?

Core Concept

A nonsense mutation resulting in a premature stop codon would most likely result in a nonfunctional protein, as it would lead to the premature termination of protein synthesis. A missense mutation would result in a conservative amino acid substitution, frameshift mutations can result in nonfunctional proteins but are not the most likely option in this case, and silent mutations result in no change to the amino acid sequence.